Somatostatin, Olfaction, and Neurodegeneration

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Topical Administration of Somatostatin Prevents Retinal Neurodegeneration in Experimental Diabetes

Retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR). Somatostatin (SST) is an endogenous neuroprotective peptide that is downregulated in the diabetic eye. The aim of the study was to test the usefulness of topical administration of SST in preventing retinal neurodegeneration. For this purpose, rats with streptozotocin-induced diabetes mellitus (STZ-DM) ...

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Olfaction.

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Lower somatostatin expression is an early event in diabetic retinopathy and is associated with retinal neurodegeneration.

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Somatostatin receptor 2 is activated in cortical neurons and contributes to neurodegeneration after focal ischemia.

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ژورنال

عنوان ژورنال: Frontiers in Neuroscience

سال: 2020

ISSN: 1662-453X

DOI: 10.3389/fnins.2020.00096